The Science & Purpose of Each Supplement
Agaricus Blazei Murrill mushroom
Agaricus Blazei mushroom is used in this protocol to help repair and enhance the power of the immune system to help the body eliminate remaining Covid virus protein traces and cause a full recovery from Long Covid.
Purpose in Protocol:
- Immune modulating
- Anti-Infection
- Anti-Allergy
- Anti-inflammatory
- Anti-cancer
Biological benefits:
Agaricus Blazei Murrill mushroom is rich in polysaccharides and β-glucans, both which have been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties, in addition to anti-inflammatory effects in inflammatory bowel disease patients.
These effects are due to the mushroom's rich s immunomodulating substances such as highly branched β-1,3-/1,6-glucans and proteoglycans. These are known ligands for CD11b/18 (complement receptor 3, CR3), dectin-1, and toll-like receptor 2 (TLR2) on monocytes, dendritic cells, granulocytes, and NK cells of the innate immune system., and the enhancement of a skewed Th1/Th2 balance and inflammation.
Agaricus Blazei Murrill popularly known as ‘Cogumelo do Sol’ in Brazil, or ‘Himematsutake’ in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinary-medicinal biotechnological species. It was traditionally used to treat many common diseases like atherosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis and cancer. In vitro (laboratory) and in vivo (real life), it has shown immunomodulatory and antimutagenic properties.
This mushroom is reported to have antitumor properties in mouse models of fibrosarcoma, myeloma, ovarian, lung, and prostate cancer, and in human studies against gynecological cancer (increased NK cell activity and quality of life) and leukemia.
Alpha-Lipoic Acid
Alpha-Lipoic Acid is used in this protocol to help protect and heal the heart and blood vessels from Long Covid and Covid-related injuries. It is also used to accelerate Long Covid recovery.
Purpose in Protocol:
- Antioxidant
- Anti-inflammatory
- Immune modulator
- Endothelial Protection (protects blood vessels)
- Protects Heart & Reduces Cardiovascular Disease
- Restores Nitric Oxide levels
- Anti-Neuropathy
- Anti-Coagulant
Biological benefits:
Alpha-Lipoic Acid has been shown to protect the heart from inflammation and cardiovascular disease, and possibly Covid-related heart injuries via vascular endothelial protective actions by reducing the ox-LDL and Lp-PLA2 mass and improving the Lp-PLA2 distribution among lipoproteins, as well as its ability to restore the endothelial nitric oxide synthase (eNOS).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348748/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085885/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446120/
Alpha-Lipoic Acid along with Coenzyme Q10 together have shown promising results in reducing Long Covid-based chronic fatigue syndrome. They each have different and complementary roles in mitochondrial function, associated with strong antioxidant actions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395797/
Andrographis Paniculata
Andrographis is used in this protocol to help eliminate the over-reactive immune response and overall Long Covid symptoms in addition to helping eradicate the Covid S1 Spike protein.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Rebuilds Gut Microbiome
Biological benefits:
Andrographolide, the key medicinal component of Andrographis is well known for its broad-spectrum antiviral properties. Andrographolide is beneficially involved in affecting multiple steps of the viral life cycle including viral entry, genetic material replication, and protein synthesis and inhibits the expression or function of the mature proteins, possibly including the Covid spike protein. Andrographolide has significant binding affinity toward the spike glycoprotein of both SARS-CoV-2 and ACE2 receptors and could be significant in limiting viral entry into the host cells.
Andrographolide has anti-inflammatory effect and significantly inhibits the expression of TNF-α, IL-6, and IL-1β in LPS-stimulated RAW264.7 cells. Its anti-inflammatory mechanism may be through the inhibition of NF-κB and MAPKs signaling pathway.
Twenty-four studies showed andrographolide is effective against influenza A, hepatitis C virus, Chikungunya virus, HIV, hepatitis B virus, Herpes simplex virus 1, Epstein–Barr virus, and human papillomavirus. This study showed that both Andrographis paniculata extract and its active component andrographolide had a potent inhibitory effect against Covid-19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056600/
Artemisinin (Artemisia annua, a Sweet Wormwood extract)
Artemisinin is used in this protocol to help deactivate the hyperimmune response and inflammation and eliminate all traces of the Covid-19 virus remnants, specifically the Covid-19 S1 protein remnant.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Immune modulator
- Anti-pulmonary fibrosis
- Anti-mucus
- Antipyretic (reduces fever)
- Anti-cancer
- Anti-bacterial (both gram positive & negative)
Biological benefits:
Artemisinin has broad spectrum antiviral properties. It can inhibit coronavirus-host proteins, including 3CLPRO, S (spike) protein, N protein, E protein, cathepsin-L, helicase protein, nsp3, nsp10, nsp14, nsp15, and GRP78 receptor. It also has significant binding affinity toward the S1 spike glycoprotein of both SARS-CoV-2 and ACE2 receptors.
Artemisinin can also inhibit several Covid-19 signaling pathways, such as: Toll-like receptors, Syk tyrosine kinase, phospholipase Cy, P13K/Akt, MAPK, STAT-1/3/5, NF-Kb, Sp1, Nrf2/ARE, IL-1b, IL-6, IL-8, PAK-1 and Th2 regulation of MMPs and VEGFs. Meanwhile it can upregulate Th1 cells.
The main bioactive compounds of Artemisia annua are the sesquiterpene lactones, monoterpenes, triterpenoids, steroids, flavonoids, and essential oils. The principal sesquiterpene of Artemisia annua is artemisinin and the artemisinin derivatives, collectively called artemisinins, include artesunate, dihydroartemisinin (DHA; aka. artenimol), artemether, arteether, arteannuin B, and artemisone, among others.
Essential oils derived from Artemisia annua include artemisia alcohol, artemisia ketone, borneol, camphene, camphene hydrate, camphor, trans-caryophyllene, β-caryophyllene, caryophyllene oxide, chrysanthenone, 1,8-cineole (eucalyptol), β-farnesene, germacrene D, α-guaiene, linalool, linalool acetate, myrcene, α-pinene, (trans)-pinocarveol, sabinene, and spathulenol.
Ashwagandha (Withania somnifera)
Ashwagandha is used in this protocol to help reduce the spike protein, help regulate the gut microbiome, repair brain and neurological injuries, lower stress, anxiety, and depression, and improve sleep and overall brain health. It is also an adaptagenic used to raise the body’s core energies.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Cognition Promoting Effect
- Xiolytic (anti-anxiety) effect
- Antidepressant
- Rebuilds Gut Microbiome
- Adaptagenic
Biological benefits:
Withaferins, the bioactive steroidal lactones from Ashwagandha, have been shown to inhibit (i) cell surface receptor protein (TMPRSS2) that is required for entry of virus to host cells and (ii) viral protein (the main protease Mpro) that is essential for virus replication. Furthermore, withanolide-treated cells showed downregulation of TMPRSS2 expression and inhibition of SARS-CoV-2 replication in vitro.
Besides its antiviral qualities, Ashwagandha has a Cognition Promoting Effect and was useful in children with memory deficit and in old age people loss of memory. It was also found useful in neurodegenerative diseases such as Parkinson's, Huntington's and Alzheimer’s diseases.
It has xiolytic (anti-anxiety) effect and improves energy levels and mitochondrial health. It is an anti-inflammatory and anti-arthritic agent and was found useful in clinical cases of Rheumatoid and Osteoarthritis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188803/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979308/
Astragalus Root
Astragalus Root is used in this protocol to repair and enhance the power of the immune system to help the body eliminate remaining Covid virus protein traces and cause a full recovery from Long Covid.
Purpose in Protocol:
- Immune modulating
- Antiviral
- Anti-bacterial
- Anti-cancer
- Anti-fibrosis
Biological benefits:
Astragalus Root is also called “Huangqi” in China. Astragalus Membranaceus is a type of traditional Chinese medicine with a long history of clinical application. Its main components are Astragalus Polysaccharide, flavonoids compounds, saponins compounds, alkaloids, etc., with Astragalus Polysaccharide with its chemical composition of different monosaccharides, being the most important natural active component that possesses multiple pharmacological properties.
Astragalus Root biological strengths are enhancing the immune organ index, promoting the proliferation of immune cells, stimulating the release of cytokines, and affecting the secretion of immunoglobulin and conduction of immune signals; anti-aging; anti-tumor by enhancing immunity, inducing apoptosis of tumor cells and inhibiting the proliferation and transfer of tumor cells; antiviral effects; regulation of blood glucose such as type I diabetes mellitus, type II diabetes mellitus and diabetic complications; lipid-lowering; anti-fibrosis; antimicrobial activities and anti-radiation.
Astragalus’ influence on immune cells mainly includes an increase in the proliferation and differentiation of B lymphocytes and T lymphocytes, regulation of the balance in the T lymphocyte subgroup, and regulation of natural killer cells and macrophages.
Dendritic cells are key in activating the immune response. Studies have shown that Astragalus facilitates the growth and maturation of dendritic cells and their antigen-presenting capacity, as well as decreases the endocytosis activity of dendritic cells. Moreover, Astragalus can markedly promote the development and maturation of bone marrow-derived dendritic cells. Astragalus activates T cells by inducing the differentiation of dendritic cells.
A recent study found that Astragalus is the first effective regulator of tumor M1/M2 macrophage polarization and an effective activator of dendritic cell maturation. Astragalus activates the proliferation of B cells and macrophages and increases the production of cytokines. Furthermore, it can activate B lymphocytes through antigen receptors on B cell membranes rather than through the toll-like receptor 4 (TLR4).
An in vivo (lab) study of mice revealed that Astragalus is able to increase complement (C3) deposition and the number of macrophages. In addition, some studies have shown that Astragalus promotes humoral immune response by regulating the functional activity of natural killer and natural killer T cells.
Black Cumin Seed oil - Nigella Sativa
Nigella Sativa is used in this protocol to reduce the over-reactive immune response and help eliminate the Long Covid symptoms. This has been extremely beneficial for me. The key ingredient is Thymoquinone which helps the body manage Mast Cell Activation Syndrome - often part of Long Covid.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Antihistamine
- Antidiabetic
- Immunomodulator
Biological benefits:
Thymoquinone, the main active constituent, reduces pro-inflammatory mediators including, IL-2, IL-4, IL-6, and IL-12, while enhancing IFN-γ. It also increases the serum levels of IgG1 and IgG2a.
As an antiviral, Nigella Sativa also can lower the expression of the ACE-2 receptor, RdRp, Mpro protease, etc. of SARS-CoV-2.
The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated that thymoquinone to be medicinally very effective against various illnesses, including several chronic illnesses: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility, as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501064/
Black Walnut Hull (Juglone)
Black Walnut Hull is used (synergistically with Gum Benzoin and Platycodon) in this protocol to help eliminate all remaining traces of the Covid-19 S1 spoke protein virus traces and reduce inflammation in the body.
Purpose in Protocol:
- Antiviral
- Antioxidant
- Promotes cell survival
Biological benefits:
Juglone, the key ingredient in Black Walnut Hull consists of a compound called 2-acetyl-8-methoxy-1,4-naphthoquinone, which has powerful antiviral properties, specifically as a potent SARS-CoV-2 main proteinase inhibitor (Mpro). It also activates mitogen-activated protein kinases.
Black Walnut Hull also has many other key medicinal properties including triterpenoids, naphthoquinones, and α-tetralones, which have important antimicrobial, antiviral, anti-cancer, and antioxidant capabilities.
The walnut fruit includes four main parts: the kernel, skin, shell, and green husk. It has been demonstrated that the walnut green husk could be valued as a source of different natural bioactive compounds with excellent antioxidant and antimicrobial properties. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372460/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719079/
Chaga Mushrooms (Inonotus obliquus)
Chaga is used in this protocol to block spike protein replication and to help the Gut microbiome eradicate any spike protein remnants. This is done in conjunction with Turkey Tail mushrooms and prebiotics & probiotics.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Rebuilds Gut Microbiome
- Immunomodulatory
Biological benefits:
Docking analysis reveals that Chaga mushroom components (beta glycan, galactomannan, and betulinic acid) binds to the S1-CTD residues of SARS-CoV-2 involved in ACE-2-RBD interaction.
Inonotus obliquus (Chaga) mushroom can also help eliminate undesirable bacteria in the gut while increasing desirable bacteria. This may help prevent the spike protein from being able to hide in the gut microbiome resulting in helping to eliminate it. Chaga mushroom, is also a natural anti-inflammatory and immune booster.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645752/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309192/
Cistus Incanus tea (Rockrose)
Cistus Incanus is used in this protocol to help eradicate the Covid S1 spike protein, eliminate the over-reactive immune response and Long Covid symptoms, and help heal the upper respiratory tract, and lower whole-body inflammation.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Antispasmodic
Biological benefits:
Has Polyphenolic compounds (gallic acid, epicatechin, vanillic acid, epigallocatechin, rutin, myricetin, and kaempferol) that block primary virus attachment to cells by selective targeting of the viral envelope glycoproteins.
This tea has been extremely beneficial for me. And according to research, it’s also a powerful antiviral drug, which also helps rid the body of HIV virus, Influenza A virus, Ebola virus and Marburg virus among others.
“Cistus Incanus extract combines broad antiviral activity with low risk of virus resistance. Its mechanism-of-action involves blocking of primary virus attachment to cells by selective targeting of the viral envelope glycoproteins. In contrast, many other natural products with broad-spectrum antiviral activity target host cell components. Our results demonstrate that multiple antiviral components within the Cistus Incanus extract block virus attachment to the host cell. Altogether, the broad and potent in vitro antiviral effects of Cistus Incanus extract demonstrated in this study support the further exploration of Cistus Incanus extract and its components for novel antiviral approaches.”
Coenzyme Q10 (CoQ10)
CoQ10 is used in this protocol to restore Coenzyme Q10 levels which also help restore mitochondrial function and healthy cell function. It is also used to protect the heart, and to increase energy production, immunity and decrease oxidative stress.
Purpose in Protocol:
- Antioxidant
- Mitochondrial Restoration
- Cardiovascular health (Protects Heart)
- Ophthalmological Protection (Eyes)
Biological benefits:
A Covid infection along with persistent Long Covid can partially block electron transfer in the respiratory chain resulting in a reduced adenosine triphosphate (ATP) production. CoQ10 supplementation has been shown to restore platelet mitochondrial respiratory chain function and oxidative phosphorylation.
https://pubmed.ncbi.nlm.nih.gov/34967652/
Coenzyme Q10, is an endogenous lipophilic quinone, ubiquitous in biological membranes, where it acts as a cofactor of mitochondrial respiratory complexes supporting cellular bioenergetics. Its reduced form (ubiquinol) is endowed with antioxidant activities both as a radical scavenger and also supporting, synergistically, the larger cellular antioxidant network.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389239/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389239/
Coenzyme Q10 along with Alpha-Lipoic Acid together have shown promising results in reducing Long Covid-based chronic fatigue syndrome. They each have different and complementary roles in mitochondrial function, associated with strong antioxidant actions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395797/
Cordyceps ssp mushroom
Cordyceps mushroom is used in this protocol to repair and enhance the power of the immune system to help the body eliminate remaining Covid virus protein traces and cause a full recovery from Long Covid.
Purpose in Protocol:
- Immune modulating
- Hypotensive (lowers high blood pressure)
- Anti-cancer
- Antioxidant
- Hypocholesterolemic (lowers lipid levels in blood)
- Anti-depressant
Biological benefits:
Cordyceps mushroom, is comprised of the following chemical compounds; nucleosides, sterols flavonoids, cyclic peptides, phenolic, bioxanthracenes, polyketides, and alkaloids. Additionally, cordycepin (3’-deoxyadenosine & 2’-deoxyadenosine) and cordycepic acid are also prominently present, as well as polysaccharide components.
Cordyceps has be shown to stimulate and modulate the immune system through cytokine production such as interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-α, phagocytosis stimulation of immune cells, nitric oxide production by increasing inducible nitric oxide synthase activity, and stimulation of inflammatory response via mitogen-activated protein kinase pathway.
Other pharmacological activities like antioxidant, anti-cancer, antihyperlipidemic, anti-diabetic, anti-fatigue, anti-aging, hypocholesterolemic, hypotensive, vasorelaxation, anti-depressant, aphrodisiac, and kidney protection, has been reported in pre-clinical studies.
Curcumin (Curcuma longa, Turmeric)
Curcumin is used in this protocol to help eliminate the over-reactive immune response, especially the hyper-inflammation that is typical of Long Covid. It may also contribute to eliminating the spike protein.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Immunomodulatory
Biological benefits:
Can reduce inflammatory cytokines via inhibiting TLR/MAPK/NF-κB signaling. May also attenuate ARDS and pulmonary fibrosis. Includes antioxidant, antiapoptotic, and antifibrotic properties with inhibitory effects on Toll-like receptors, NF-κB, inflammatory cytokines and chemokines, and bradykinin.
Research suggests that curcumin can help in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia (too much fat or cholesterol). It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and subsequent performance in active people.
Curcumin supplementation may potentially protect from SARS-CoV-2 infection as an antiviral by down-regulating ACE2 expression.
Curcumin has some useful clinical effects such as antiviral, antinociceptive, anti-inflammatory, antipyretic, and antifatigue effects that could be effective to manage the symptoms of the infected patient with COVID-19. Scientific evidence suggests that curcumin could have a potential role to treat COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590269/
Desmodium Molliculum (Burbur)
Burbur is used in this protocol to help detox the body, kidneys, lymphatic system and especially the liver from toxins related to Covid, Long Covid and virus remnant elimination.
Purpose in Protocol:
- Protects liver
- Detoxifies kidneys
- Detoxifies lymphatic system
Biological benefits:
Burbur, also called Desmodium Molliculum, is made from an extract from the leaves of Desmodium Molliculum, a genus of the flowering plant family Fabaceae, a perennial that has been found and harvested in areas of Peru as high as 3,500 meters above sea level. Burbur leaf extract has been traditionally used for its body cleansing properties including the detoxification of the liver, kidneys, lymphatic system, and connective tissue.
EDTA (calcium disodium ethylenediaminetetraacetic acid)
EDTA is a chelation agent used in this protocol to help perform a final detox of the brain and the cleanup of heavy metals and other toxins leftover from the initial Covid infection, Long Covid and the elimination of the Covid virus protein remnants.
Purpose in Protocol:
- Eliminates heavy metals form body and brain
- Helps dissolve plaque buildup in heart and body
Biological benefits:
Neurotoxicity can be caused by numerous direct agents, of which toxic metals, organophosphorus pesticides, air pollution, radiation and electromagnetic fields, neurotoxins, chemotherapeutic and anesthetic drugs, and pathogens are the most important. Other indirect causes of neurotoxicity are cytokine and/or reactive oxygen species production and adoptive immunotherapy.
The chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA) -previously used to treat cardiovascular diseases-is known to be useful for the treatment of neurodegenerative diseases by removing these toxins.
Electrolytes
Electrolytes are used in this protocol to help restore the body’s electrolyte and potassium levels and help rehydrate the body. These nutrients are consumed as part of a daily beverage so the body and brain can heal more efficiently.
Purpose in Protocol:
- Rehydration
- Can speedup healing
- Increases body strength
Biological benefits:
Electrolytes are essential for basic life functioning, such as maintaining electrical neutrality in cells, generating, and conducting action potentials in the nerves and muscles. Sodium, potassium, and chloride are the significant electrolytes along with magnesium, calcium, phosphate, and bicarbonates.
There are several supplemental powders available on the market that can be used to accomplish this. The one that was readily available when I did the protocol was Liquid I.V.®. I have since been using LMNT (https://drinklmnt.com/) which is sugar free.
Ginseng (Panax Quinquefolius)
Ginseng is used in this protocol to help eliminate the over-reactive immune response and help rebuild the body’s depleted core energy reserves. It can also possibly protect the body from fibrin amyloid microclots.
Purpose in Protocol:
- Anti-inflammatory
- Antioxidant
- Anti-clotting
- Antihistamine
- Neuroprotective effects
- Neurogenic
- Anti-diabetic
- Anti-cancer
- Adaptagenic
Biological benefits:
The active ingredients in Ginseng, Ginsenosides and Saponins, have been observed to hinder inflammation by inhibition of inflammatory-related mediator nitric oxide (NO) and cytokines, including tumor necrosis factor (TNF), interleukin 6 (IL-6), and interleukin 1.
Can positively affect memory processes; induces synthesis of acetylcholine in the hippocampus by stimulating choline acetyltransferase; induces apoptosis and inhibits angiogenesis in cancer cells; inhibits the release of inflammatory leukotrienes; reversibly and tonically blocks voltage-dependent Na+ channels in the brain reducing detrimental effects of hypoxia; downregulates the COX-2 gene; stabilizes neutrophils and lymphocytes; inhibits the release of histamine; blocks calcium channels and stabilized the heart; reduces blood sugar levels; anti-diabetic, insulin-sensitizing and anti-obesity actions; neurotropic, neuroprotective, oestrogen-like activity; stimulates GABA receptors and induces a depressive effect on brain function, which underlines its calming, anxiolytic, sleeping, relaxing and antipsychotic effects.
Ginseng also provides a variety of therapeutic effects, including antioxidation, anti-inflammatory, vasorelaxation, antiallergic, antidiabetic, and anticancer.
Research shows that ginseng has beneficial effects on cardiac and vascular diseases through efficacy, including antioxidation, control of vasomotor function, modulation of ion channels and signal transduction, improvement of lipid profiles, adjustment of blood pressure, improvement in cardiac function, and reduction in platelet adhesion.
Gum Benzoin (Styrax)
Gum Benzoin is used (synergistically with Black Walnut Hull and Platycodon) in this protocol to help eliminate the remaining traces of the Covid-19 virus specifically the S1 spike protein.
Purpose in Protocol:
- Antiviral
- Anti-biofilm
- Xiolytic (anti-anxiety) effect
- Decongestant
Biological benefits:
Gum Benzoin is comprised of the following constituents: Benzaldehyde, Benzioc Acid, Benzyl Benzoate, Cinnamic Acid, and Pinoresinol. It shows strong antiviral activity against SARS-CoV-2 main protease, blocks SARS-CoV-2 via the active site of ACE2 receptor.
It is used for many ailments and is known for its antibacterial, anti-biofilm and anticancer properties. The main medicinal ingredients are:
- Benzioc Acid, which shows strong antiviral activity against SARS-CoV-2 main protease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770597/
- Cinnamic Acid, which has shown to block Covid-19 via the active site of ACE2 receptor. https://pubmed.ncbi.nlm.nih.gov/33981493/
- Pinoresinol, is extensively used as anticancer and antiviral agent. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018901/
https://www.researchgate.net/publication/336825434_A_review_on_bioactive_potential_of_Benzoin_Resin
Licorice Root (Glycyrrhiza glabra)
Glycyrrhiza glabra is used in this protocol to help inhibit Covid viral activity and replication by blocking the viral main protease.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Liver protection
- Anti-Cancer
- Antibacterial
Biological benefits:
Glycyrrhizin, the primary active ingredient of the licorice root, potently inhibits SARS-CoV-2 replication in vitro. The underlying mechanism that blocks the viral replication does so by inhibiting the viral main protease Mpro that is essential for viral replication.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066091/
Licorice is one of the most effective herbal medications for reducing toxicity and increasing the efficacy of other herbal medicines when used together. Licorice extracts and licorice flavonoids have been exploited for the activities such as hepatoprotective, anticancer, antibacterial, respiratory tract infections, and cardiovascular diseases.
Important: Licorice Root should not be taken for a duration longer than ten weeks as it can build up in the body and increase blood pressure if taken for too long and at too high of doses. Avoid extracts that can be much too potent for safe use. Do not exceed 500 mg per day.
Lion’s Mane Mushroom (Hericium Erinaceus)
Lion’s Mane mushroom is used in this protocol to help reduce inflammation, and protect and heal the brain and nervous system from any damage caused by the initial Covid-19 infection and Long Covid. It also shows evidence of eliminating depression, anxiety, and possibly protecting the pancreas and reducing incidence of diabetes.
Purpose in Protocol:
- Anti-inflammatory
- Antioxidant
- Anti-depressant
- Xiolytic (anti-anxiety) effect
- Anti-diabetic
- Anti-cancer
- Neurogenic
- Neurotrophic
Biological benefits:
Lion’s Mane is comprised of the following constituents: Hericenones A-K, Erinacine A-F, H, ergosterol peroxide, cerevisterol, and 3β,5α,9α-trihydroxy-ergosta-7,22-dien-6-one, and amycenone.
Lion’s Mane has been shown to enhance nerve growth factor (NGF) activity to promote neurite outgrowth. Erinacines belong to a group of cyathin diterpenoids and have been shown to induce NGF synthesis.
Additionally, amycenone isolated from the fruiting body of H. erinaceus exhibited anti-inflammatory activity that alleviated the inflammation-associated depression. Of particular interest, the ethanolic extract of H. erinaceus mycelium was found to modulate the expression level of serotonin, noradrenaline, and dopamine, as well as the BDNF signaling.
Anti-depressant effects could be through an anti-inflammatory response via modulating the expression levels of IL-6, TNF-α, and NF-κB, and via rain-derived neurotrophic factor (BDNF). Evidence-based studies have shown that Lion’s Mane can delay neuronal cell death with neurodegenerative diseases, such as ischemic stroke, Parkinson's disease, Alzheimer's disease, and depression.
Moreover, results have indicated that it can promote functional recovery and enhance nerve regeneration with neuropathic pain or presbycusis.
Maitake mushroom (Grifola frondose)
Maitake mushroom is used in this protocol to repair and enhance the power of the immune system to help the body eliminate remaining Covid virus protein traces and cause a full recovery from Long Covid.
Purpose in Protocol:
- Immune modulating
- Gut microbiome enhancer
- Anti-tumor
- Antiviral
- Antibacterial
- Anti-diabetic
- Antioxidant
- Anti-hypertension
Biological benefits:
Maitake mushroom, also called sheep’s head, king of mushrooms, hen-of-the-woods, and cloud mushroom, is rich in β-glucans and heteroglycans which have shown significant antitumor and immunomodulatory activities.
These immunomodulatory components have been shown to enhance the actions of macrophages and many other immune-related cells, such as cytotoxic T-cells and natural killer (NK) cells.
Furthermore, Maitake mushroom components could increase the secretion of cytokines, which are signaling molecules, including interferons (IFN), interleukins (IL), tumor necrosis factors (TNF) and lymphokines with antiproliferative (suppresses cancer cell growth) activity, causing apoptosis (cell death) and differentiation in tumor cells, thus further increasing the efficiency of immune-related cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824844/
Lab results show that Maitake mushroom taken together with Shiitake mushroom has a more powerful synergistic effect than just taking Maitake and Shiitake alone. This combination caused significant stimulation of immune system defense reaction.
In all cases, the most active was the Maitake-Shiitake combination, with Maitake alone being the second strongest, followed by Shiitake on its own. This combination strongly stimulated both the cellular and humoral branch of immune reactions.
Melatonin
Melatonin is used in this protocol to help deactivate the hyperimmune reaction and spike protein activity of Long Covid, as well as help with insomnia, anxiety and depression.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Xiolytic (anti-anxiety) effect
- Sleep enhancement
- Anti-fibrotic
Biological benefits:
Melatonin has a broad spectrum of potential pharmacological effects that can contribute to reducing Covid and Long Covid activity and symptoms.
As an antiviral, there is indirect evidence that suggests a possible interference of melatonin in the SARS-CoV-2/ACE2 interaction, including through suppression of calmodulin, an essential intracellular component for maintaining ACE2 on the cell surface.
In addition to ACE2, another significant receptor for SARS-CoV-2 has also been identified - cluster of differentiation 147 (CD147) or basigin or extracellular matrix metalloproteinase inducer.
CD147 is a glycoprotein that is responsible for the cytokine storm manifestations in COVID-19. CD147 is involved in inflammation which develops through pro-inflammatory cytokines, such as interleukin-6 (IL-6), interferon-gamma (IFN-γ), tumor-necrosis factor-α (TNF-α), and monocyte chemo-attractant protein-1 (MCP-1). Severity correlates with high levels of pro-inflammatory cytokines: TNF-α, IFN-γ, IL-6, IL-10, and C-reactive protein (CRP).
Melatonin has been shown to reduce the remodeling effects of angiotensin II on the myocardium by blocking CD147 activity. According to experimental studies, melatonin reduces the level of pro-inflammatory cytokines, such as IL-6, and it can be assumed that this effect is also due to inhibition of the CD147-pathway.
Milk Thistle (Silymarin)
Milk Thistle or Silybum marianum is used in this protocol to protect and detox the liver, help eliminate the spike protein, deactivate the over-reactive immune response and symptoms of Long Covid, and help strengthen the immune system. It can also potentially help prevent damage caused by fibrin amyloid microclots.
Purpose in Protocol:
- Hepatoprotective
- Antiviral
- Anti-inflammatory
- Anti-coagulant
- Anti-platelet
- Antioxidant
- Immune-modulating
Biological benefits:
Silymarin, is a flavonolignan with diverse pharmacological activity having anti-inflammatory, antioxidant, antiplatelet, and antiviral properties, with versatile immune‐cytokine regulatory functions, that able to bind with transmembrane protease serine 2 (TMPRSS2) and induce endogenous antiviral cytokine interferon‐stimulated gene 15, for the management of COVID-19.
Silymarin inhibits the expression of host cell surface receptor TMPRSS2 with a docking binding energy corresponding to −1,350.61 kcal/mol and a full fitness score of −8.11. The binding affinity of silymarin with an impressive virtual score exhibits significant potential to interfere with SARS-CoV-2 replication.
Chemically silymarin is a polyphenolic flavonolignan complex of seven closely related derivatives (silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, and silydianin) with one flavonoid taxifolin.
Silymarin also blunts the enzymatic activity of cathepsin‐B in ovarian cancer (Momeny et al., 2016); where overexpression of cathepsin B induces elevated production of TNF‐α and IL‐6, followed by inflammation.
Moreover, silymarin alleviates the activity of both cathepsin B and cathepsin L along with the oxidative stress in TNBS‐induced colitis.
Evidence-based research shows the multi-faceted capacity of Silymarin to target the host cytokine storm and the virus lifecycle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250558/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356916/
N-Acetyl-L-Cysteine (NAC)
NAC is used in this protocol to help eliminate the over-reactive immune response and symptoms of Long Covid.
Purpose in Protocol:
- Anti-inflammatory
- Antioxidant
- Immune-modulating
Biological benefits:
NAC has antioxidant, anti-inflammatory and immune-modulating characteristics that may prove beneficial in the treatment and prevention of SARS-Cov-2. NAC can also boost the immune system, suppress viral replication, and reduce inflammation. Potential therapeutic benefits of NAC include, extracellularly scavenging ROS radicals, replenishing intracellular GSH, suppression of cytokine storm, and T cell protection, thus mitigating inflammation and tissue injury.
“We can take a lot of "antioxidants" but N-Acetyl-L-cysteine is the precursor to Glutathione which is the only antioxidant made in the body, and the only antioxidant that we know works intracellularly” according to Dr. William Lenaburg, MD.
Nattokinase
Nattokinase is used in this protocol to protect the heart and other organs by reducing fibrin amyloid microclots activity and help eliminate the Covid S1 Spike protein remnants remaining in the body.
Purpose in Protocol:
- Fibrinolytic (prevents and dissolves blood clots)
- Protects the heart
- Antiviral (helps eliminate spike protein)
Biological benefits:
Nattokinase protects the heart via its potent fibrinolytic activity, antihypertensive, anti-atherosclerotic, and lipid-lowering, antiplatelet, and neuroprotective effects.
Nattokinase not only degrades fibrin directly and effectively but also increases the release of tissue plasminogen activator (tPA) with a subsequent increase in the formation of plasmin. Plasminogen activator inhibitor 1 (PAI-1) is the primary inhibitor of tPA and regulates fibrinolytic activity in the fibrinolytic cascade.
In a study investigating the mechanism by which Nattokinase exerted its fibrinolytic effect, Nattokinase enhanced fibrinolysis through cleavage and inactivation of PAI-1.4 In this study, Nattokinase was shown to cleave active recombinant prokaryotic PAI-1 into low-molecular-weight fragments as well as enhance tissue-type plasminogen activator–induced fibrin clot lysis. The enhanced fibrinolytic activity observed in the absence of PAI-1 appeared to be induced through direct fibrin dissolution by Nattokinase.
Nattokinase also enhanced the production of clot-dissolving agents such as urokinase through the conversion of prourokinase to urokinase. Furthermore, Nattokinase was shown to be capable of blocking thromboxane formation resulting in an inhibition of platelet aggregation without producing the side effect of bleeding. Thus, Nattokinase was found to be a potent antithrombotic agent, and, by reducing thrombus formation, was able to slow the progression of plaque formation and reverse evolving atherosclerotic lesions.
Nattokinase has also been shown to degrade the Covid S1 spike protein. It has a degrading effect on not only S proteins but also ACE2 in host cells.
Nettle Leaf (Urtica dioica L.)
Stinging Nettle is used in this protocol as an antiviral to help reduce the Covid-19 viral load in the body. It can also protect the kidneys and lungs, as well as many other health benefits for people with Long Covid.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Immunomodulator
- Improves blood circulation and heart health
- Improves gastrointestinal health
- Treats respiratory problems
- Anti-diabetic
Biological benefits:
Stinging Nettle can suppress the expression of NF-κB and the activity of the proinflammatory cytokines TNF-α, IL-1, and IL-6. Evidence has also shown that Nettle Leaf can act as an immunomodulator. It can bolster the nonspecific and cell-mediated immune response. This may be accomplished by increasing the production of neutrophils and T lymphocytes. Nettle Leaf may be an effective adjunct therapy for treating Covid infections, as it can regulate inflammation and the immune function.
Nettle Leaf potently blocks transduction of pseudotyped SARS-CoV-2 in A549.ACE2+-TMPRSS2 cells, with IC50 values ranging from 0.32 to 1.22 µM. Furthermore, Nettle Leaf prevents viral replication of the early Wuhan-Hu-1 strain in Vero E6 cells (IC50 = 225 nM), but also the replication of SARS-CoV-2 variants of concern, including Alpha, Beta and Gamma (IC50 ranging from 115 to 171 nM). In addition, Nettle Leaf exerts antiviral activity against the latest circulating Delta and Omicron variant in U87.ACE2+ cells (IC50 values are 1.6 and 0.9 µM, respectively). Importantly, when tested in Air-Liquid Interface (ALI) primary lung epithelial cell cultures, Nettle Leaf preserves antiviral activity against SARS-CoV-2 (20A.EU2 variant) in the nanomolar range.
Surface plasmon resonance (SPR) studies demonstrated a concentration-dependent binding of Nettle Leaf to the viral spike protein of SARS-CoV-2, suggesting interference of Nettle Leaf with cell attachment or subsequent virus entry. Moreover, in additional mechanistic studies with cell-cell fusion assays, Nettle Leaf inhibited SARS-CoV-2 spike protein-mediated membrane fusion. Finally, pseudotyped SARS-CoV-2 mutants with N-glycosylation deletions in the S2 subunit of the spike protein remained sensitive to the antiviral activity of Nettle Leaf. In conclusion, Nettle Leaf is a potent fusion inhibitor for the current variants of SARS-CoV-2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468479/
Nicotinamide Riboside (for NAD+)
Nicotinamide Riboside is used in this protocol to help eliminate brain fog, and replenish NAD+ (nicotinamide adenine dinucleotide) levels which can be depleted by Covid-19. It can also eliminate the over-reactive immune response, hyper-inflammation, and overall symptoms of Long Covid.
Purpose in Protocol:
- Anti-inflammatory
- Increases NAD+
- Promotes cell regeneration
- Promotes muscle growth
Biological benefits:
As an inti-inflammatory, it can significantly decrease the levels of the interleukins IL-6 (Figure 6A), IL-5, and IL-2 and tumor necrosis factor alpha (TNF-α). For muscle growth, it augments the aged human skeletal muscle NAD+ metabolome while inducing a transcriptional signature without affecting mitochondrial function or systemic cardiometabolic parameters.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702140/
Low NAD+ levels can cause heart and neurological problems as well as slowing down cell regeneration, which is a key to healing. Low NAD+ levels can also lower serotonin levels which contribute to depression.
https://www.nature.com/articles/s42255-021-00507-3
There’s also evidence suggesting that NAD may help the body repair neuronal stress or stress that occurs in the brain’s neurons in animal test subjects. This indicates that NAD+ supplements may protect the brain against memory loss. Scientific research also suggests that NAD+ may increase endurance and strengthen the muscles, and lengthen lifespans by improving mitochondrial functions.
Pimpinella Anisum (Pinella)
Pinella, or Anise Oil, is used in this protocol to help protect and detox the brain and nervous system, and to lower inflammation.
Purpose in Protocol:
- Neuroprotective (Protects brain and nervous system)
- Anti-convulsant (Anti-seizure)
- Anti-hypoxia (protects brain from low oxygen)
Biological benefits:
An herbal extract made from Pimpinella Anisum, commonly known as Anise, has been used by indigenous groups for centuries. Primary benefits of this cleanse include reducing inflammation, the elimination of toxins from both the brain and central nervous systems and reducing brain fog.
Pimpinella Anisum significantly reduces the quantity and severity of epileptic seizure attacks and helps protect the brain from trauma and lack of oxygen.
Platycodon grandiflorus
Platycodon is used in this protocol to help eliminate leftover traces of the Covid-19 virus, specifically the S1 spike and N proteins. It appears to work synergistically with Gum Benzoin and Black Walnut Hull. It also has many other benefits to help heal from Long Covid.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Anti-tussive (relieves coughing and asthma)
- Immune modulating
- Antibacterial
- Anti-tumor
- Anti-obesity
- Anti-fibrosis
- Liver Protection
- Reduces Blood lipids
- Hypoglycemic
Biological benefits:
As an antiviral, Platycodin D, a triterpenoid saponin, which is a compound abundant in Platycodon grandiflorus, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. It effectively blocks the two main SARS-CoV-2 infection routes via lysosome- and transmembrane protease serine 2 (TMPRSS2)-driven entry.
Mechanistically, Platycodin D prevents host entry of SARS-CoV-2 by redistributing membrane cholesterol to prevent membrane fusion, which can be reinstated by treatment with a Platycodin D -encapsulating agent. Furthermore, the inhibitory effects of Platycodin D are recapitulated by the pharmacological inhibition or gene silencing of NPC1.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143993/
As an anti-inflammatory, Platycodin D, was shown to inhibit the production of pro-inflammatory cytokines IL-6, IL-12 p40, and TNF-α in lipopolysaccharide-stimulated murine RAW264.7 macrophage cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348564/
It also has additional high medicinal value, containing active ingredients beneficial to the human body. It has cough-relieving and anti-asthma activities, anti-tumor, anti-inflammatory and antibacterial, antioxidation, hypoglycemic, liver protection, improves human immunity and other broad pharmacological activities.
Probiotics
Probiotics are used in this protocol to help rebuild the gut microbiome, strengthen the immune system, and reduce overall body inflammation.
Purpose in Protocol:
- Antiviral
- Rebuilds Gut Microbiome
- Immunomodulator
Biological benefits:
The probiotic, Bacillus Coagulans, along with the prebiotic, Fructooligosaccharide have been shown to survive harsh digestive conditions, so are not easily killed by stomach acid.
Studies show significantly improved Irritable Bowel Syndrome (IBS) and other IBS-associated symptoms like bloating and cramping, diarrhea and constipation, nausea, vomiting, and anxiety, as well as reduction in abdominal discomfort, bloating, staining, urgency, incomplete evacuation, and passage of gas after 8 weeks of treatment.
Psilocybin Mushroom
Psilocybin is used in this protocol to help heal the brain via its neurogenesis capabilities, reduce depression and anxiety via neuroplasticity, reduce brain fog, and help recover lost memories. It also can boost the immune system and help heal the gut microbiome and gut-brain connection.
Purpose in Protocol:
- Neurogenic
- Neuroplasticity
- Anti-inflammatory
- Rebuilds Gut Microbiome
- Immune-modulating
- Anti-depressant
- Anti-migraine & cluster headaches
Biological benefits:
Psilocin, the active ingredient in Psilocybin, reacts agonistically with serotonin (5-hydroxytryptamine) type 2A (5-HT2A) receptors. Anti-depressant properties of psilocybin are mediated via modulation of the prefrontal and limbic brain regions, with the inclusion of the amygdala.
5-HT2A activation and subsequent activation of postsynaptic α-amino-٣-hydroxy-٥-methyl-٤-isoxazole propionic acid (AMPA) receptors by psilocybin is associated with increased glutamate concentration. Glutamate is responsible for normal, healthy brain functioning.
There is strong evidence showing substantial decreases in depression and anxiety symptoms that appear to persist for at least six months after a single active treatment of Psilocybin. Such results are unprecedented in psychiatry.
For example, according to studies found in the NIH library, no current pharmaceutical antidepressant appears to work as effectively as Psilocybin long term. Psilocybin has also shown promising results for: Obsessive-Compulsive Disorder, PTSD, Cluster Headaches, Addiction, Treatment-Resistant Depression, and Cancer-Related Psychiatric Distress.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487743/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509636/
Pterostilbene
Pterostilbene is also used in this protocol to help eliminate the over-reactive immune response and overall Long Covid symptoms, and to increase the effect of Nicotinamide Riboside in raising NAD+ levels in the body.
Purpose in Protocol:
- Anti-inflammatory
- Antioxidant
- Antiviral
- Anticarcinogenic
- Cardiovascular protection
- Increases NAD+ along with Nicotinamide Riboside
Biological benefits:
Pterostilbene is a s potent sirtuin activator found in blueberries. The active chemical compound is trans-3,5-dimethoxy-4-hydroxystilbene.
Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway. Pterostilbene may also have numerous preventive and therapeutic properties in a vast range of human diseases that include neurological, cardiovascular, metabolic, and hematologic disorders.
The antioxidant activity of pterostilbene has been implicated in anti-carcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. It is recommended to not exceed 50 mg of Pterostilbene per day.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522043/
Quercetin
Quercetin is used in this protocol to help eliminate the over-reactive immune response and overall Long Covid symptoms, especially hyper-inflammation, in addition to helping eliminate the Covid S1 Spike protein.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
Biological benefits:
Quercetin suppresses the NLRP3 inflammasome by affecting these regulators. Quercetin also binds with the viral S-protein-human ACE2 receptor interface, effectively blocking the spike protein from replicating.
Quercetin, as an anti-inflammatory, antioxidant, analgesic and inflammatory compound, is probably a potential treatment for severe inflammation and one of the main life-threatening conditions in patients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840793/
Quercetin also acts as a zinc ionophore. This means that quercetin transfers or pushes zinc into your body's cells, which prevents the cells from becoming infected. Zinc is also an important mineral that can lessen the duration of colds and viruses.
Reishi mushroom (Ganoderma lucidum)
Reishi mushroom is used in this protocol to repair and enhance the power of the immune system to help the body eliminate remaining Covid virus protein traces and cause a full recovery from Long Covid.
Purpose in Protocol:
- Immune modulating
- Anti-inflammatory
- Anti-tumor
- Anti-ulcer
Biological benefits:
Reishi mushroom, also called Lingzhi, is comprised of polysaccharides, peptidoglycans, and triterpenes, that have been shown to exhibit a broad range of bioactivities, including anti-inflammatory, hypoglycemic, antiulcer, antitumorigenic, and immune-stimulating effects.
Different compounds in the Reishi mushroom have been proven to enhance the proliferation and maturation of T and B lymphocytes, splenic mononuclear cells, NK cells, and dendritic cells in culture in vitro (lab) and in animal studies in vivo (real world).
In normal BALB/c mice, a polysaccharide-rich extract of Reishi mushroom promoted the proliferation of splenocytes and enhanced the activities of macrophages and NK cells, which resulted in the increase of IL-6 and IFN-γ. It also activated the gene expression of IL-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α.
A polysaccharide fraction (F3) was shown to enhance both adaptive and innate immunities by triggering the production of cytokines IL-1, IL-6, IL-12, IFN-γ, TNF-α, and colony stimulating factors (CSFs) from mouse splenocytes.
It was reported also that TNF-α and IL-6 production were stimulated in human and murine macrophages. This effect might be due to increased synthesis of nitric oxide (NO) induced by β-D-glucan. These polysaccharides were also found to be highly suppressive to tumor cell proliferation in vivo while enhancing the host’s immune response
Serrapeptase
Serrapeptase is used in this protocol to help breakdown Biofilms where the Covid-19 virus protein remnants can hide. It also helps reduce inflammation and the overreactive immune response. It can also protect the body’s organs from damage caused by fibrin amyloid microclots.
Purpose in Protocol:
- Anti-inflammatory
- Anti-biofilm
- Antiviral
- Fibrinolytic (prevents and dissolves blood clots)
- Immune-modulating
- Mucolytic agent (prevents and dissolves mucous)
- Analgesic (reduces pain)
- Antihistamine
- Antioxidant
Biological benefits:
Serrapeptase, also called Serratiopeptidaseis, is a Proteolytic Enzyme that has many benefits in helping heal from Long Covid.
As a serine protease anti-inflammatory, Serrapeptase has been shown to reduce inflammatory cytokines and adhesion molecules, thus regulating inflammatory cells movement to the site of inflammation.
It has also been shown to inhibit interleukin (IL)-6 cytokines as well as the overproduction of bradykinins.
Serrapeptase is also highly effective at preventing and dissolving biofilms, which have been shown to hide viruses, bacteria and other pathogens from the body’s immune system. Dissolving these biofilms releases and exposes these pathogens so they can be removed by the immune system. Serrapeptase is especially effective against Staphylococcus aureus-based biofilms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265778/
Shiitake mushroom (Lentinula edodes)
Shiitake mushroom is used in this protocol to repair and enhance the power of the immune system to help the body eliminate remaining Covid virus protein traces and cause a full recovery from Long Covid.
Purpose in Protocol:
- Immune modulating
- Anti-inflammatory
Biological benefits:
Shiitake mushroom has been shown to stimulate the immune system and increase the amount and effectiveness of several immune system cells, specifically T-cells and Natural Killer (NK-T) cells.
A clinical trial has shown that consuming Shiitake mushrooms for just four weeks increase the quantity of γδ-T-cells by 60%, and Natural Killer NK-T) cells by 100%. Both cell types also demonstrated a greater ability to express activation receptors, suggesting that consuming Shiitake mushrooms improved cell effector function.
The increase in secretory immunoglobulin A (sIgA) in saliva, has been shown to improve gut immunity. The reduction in C-reactive protein (CRP) suggests that Shiitake lowers inflammation.
The pattern of cytokines secreted before and after Shiitake mushroom consumption was significantly different; consumption resulted in increased interleukin (IL)-4, IL-10, tumor necrosis factor (TNF)-α, and IL-1αlevels, a decreased macrophage inflammatory protein-1α/chemokine C-C ligand 3 (MIP-1α/CCL3) level, and no change to IL-6, IL-1β, MIP-1β, IL-17 and interferon (IFN)-γ levels.
https://pubmed.ncbi.nlm.nih.gov/25866155/
Lab results show that Maitake mushroom taken together with Shiitake mushroom had a more powerful synergistic effect than just taking Maitake and Shiitake alone. This combination caused significant stimulation of immune system defense reaction.
In all cases, the most active was the Maitake-Shiitake combination, with Maitake alone being the second strongest, followed by Shiitake on its own. This combination strongly stimulated both the cellular and humoral branch of immune reactions.
Stevia Rebaudiana
Stevia is used in this protocol to help breakdown Biofilms where the Covid-19 S1 spike protein can hide, and help eradicate the spike protein virus traces. It can also be used to help sweeten the Cistus Incanus tea.
Purpose in Protocol:
- Antiviral
- Anti-biofilm
- Liver protection
Biological benefits:
Stevia Rebaudiana is comprised of the following compounds: Stevioside, steviol glycosides, steviolbioside, rebaudiosides, and Dulcoside.
Stevia has marked virustatic and virucidal properties, shown to reduce Coronavirus titers by 0.66 lg TCD50. Can dissolve existing biofilms, and prevent new biofilm growth, where spike protein might hide.
Additionally protects liver by upregulated Nrf2, thereby counteracting oxidative stress, and prevented necrosis and cholestasis through modulation of the main proinflammatory cytokines via NF-κB inhibition.
Viruses and bacteria in biofilms are enclosed by an extracellular matrix that gives protection and improves survival of that virus or bacteria. Previous studies have shown that viruses such as Covid-19 can secondarily colonize preexisting biofilms, and viral biofilms have also been described.
Stevia extracts have effectively suppressed the activity of human retroviruses (HRV) by blocking the binding of virus with susceptible cells.
Unlike pharmaceutical antivirals like Remantadine, solutions of purified Stevia extract had marked virustatic and virucidal properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089513/pdf/11094_2009_Article_270.pdf
Tryptophan (L-Tryptophan)
Tryptophan is used in this protocol to help reduce overall Long Covid symptoms, exhaustion, and help with sleep, depression and anxiety.
Purpose in Protocol:
- Helps with depression & anxiety
- Helps normalize sleep patterns
- Rebuilds muscle mass and strength
Biological benefits:
L-Tryptophan is an essential amino acid that is obtained primarily through dietary intake in humans. Besides being a building block for protein synthesis, it serves as a precursor for some important biological molecules such as serotonin, melatonin, and tryptamine.
A Covid-19 infection has been shown to cause long-term dysregulation of Tryptophan absorption from the intestines due to an ACE2 imbalance in the gastrointestinal system. Furthermore, Tryptophan metabolism is disturbed in favor of the kynurenine pathway. This results in low serum and muscle tryptophan levels, as well as elevated kynurenine levels, which may be to blame for COVID-19’s most common long-term symptoms, such as depression, sleep disturbances, fatigue, and muscle weakness—which are similar to the symptoms of tryptophan deficiency.
This Tryptophan depletion can also cause the release of several proinflammatory cytokines, such as tumor necrosis factor-α, interferons, and prostaglandins.
Tryptophan also plays a major role in skeletal muscle mass regulation, as research shows a reversible muscle loss in mice fed a tryptophan-deficient diet. In addition to lung damage, long-term dyspnea (trouble breathing) from COVID-19 may be caused by weakness of the diaphragm muscle due to relative tryptophan deficiency.
Turkey Tail Mushroom (Trametes versicolor)
Turkey Tail is used in this protocol to help the Gut microbiome eradicate any spike protein remnants. This is done in conjunction with Chaga mushrooms and prebiotics and probiotics.
Purpose in Protocol:
- Immune-modulating
- Rebuilds Gut Microbiome
- Anti-inflammatory
- Anti-cancer
Biological benefits:
Polysaccharopeptide (PSP) is the active medicinal ingredient and has shown antitumorigenic and immunomodulatory effects, for example, elimination of prostate cancer stem cells and control of the intestinal microbiome, and its interplay with host cells as a prebiotic.
Trametes versicolor has been well recognized for its activity in maintaining the general health of the population and in managing and treating human diseases in various cultures.
Zeolite Clinoptilolite
Zeolite is used in this protocol to help eradicate the Covid S1 spike protein, detox the body and brain, and mop-up residual heavy metals, virus remnants and other toxins or poisons. It can also help keep the gut microbiome healthy.
Purpose in Protocol:
- Anti-inflammatory
- Antioxidant
- Immune-modulating
- Rebuilds Gut Microbiome
- Detoxifier
- Chelation
Biological benefits:
Zeolite clinoptilolite (ZC) reduces ammonia concentration and improves the integrity of the intestinal barrier. Furthermore, ZC acts on intestinal lymphoid tissues with a positive impact on the intestinal ecosystem and boosting the immune system.
Zeolite is a safe and excellent detoxifying, antioxidant, and anti-inflammatory agent. Zeolite, sometimes called “The Magic Stone,” is a porous volcanic mineral with high absorbency and ion-exchange capacity. The molecular structure is a dense network of Sodium Aluminate and Silicon-Oxygen Tetrahedrons that generates cavities where water and other polar molecules or ions are inserted/exchanged.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515299/ https://pubmed.ncbi.nlm.nih.gov/26268084/ https://protomfitness.co.uk/blog/2015/12/17/amazing-health-benefits-of-zeolites/
And here’s interesting information from a company that sells Zeolite:
https://www.therechargeclinic.com/post/everything-you-need-to-know-about-zeolite-for-detox
Zinc
Zinc is used in this protocol to help eliminate the Covid S1 spike protein remnant, and reduce the over-reactive immune response and symptoms of Long Covid. It is also used as a general antiviral therapy and immunomodulatory agent.
Purpose in Protocol:
- Antiviral
- Anti-inflammatory
- Antioxidant
- Anti-clotting
Biological benefits:
Zinc decreases Sirt-1 activity thereby likely decreasing ACE-2 expression and thus viral entry into cells. Zinc prevents fusion with the host membrane, decreases the viral polymerase function, impairs protein translation and processing, blocks viral particle release, and destabilizes the viral envelope. Zinc along with zinc ionophore Quercetin, can decrease RNA synthesis in influenza, poliovirus, picornavirus, the equine arteritis virus, and SARS-CoV by directly inhibiting the RNA-dependent RNA polymerase of the virus.
It directly inhibits viral replication and balances the immune response during infectious diseases.
Quercetin acts as a zinc ionophore that makes it so that Zinc can enter cells more easily, thereby protecting many more cells from getting infected, slowing down the infection.
Zinc supplementation also improves the mucociliary clearance (lung defense), strengthens the integrity of the epithelium (layers of protective cells), decreases viral replication, preserves antiviral immunity, attenuates the risk of hyper-inflammation, supports anti-oxidative effects and thus reduces lung damage and minimized secondary infections.
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